Algorithm for optimized mRNA design improves stability and immunogenicity
Nature, 2023. [All Versions]. Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19, but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the…
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A high-level programming language for generative protein design biorxiv.org
2022. [All Versions]. Combining a basic set of building blocks into more complex forms is a universal design principle. Most protein designs have proceeded from a manual bottom-up approach using parts created by nature, but top-down design of proteins is fundamentally hard due…
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Learning the language of viral evolution and escape science.org
Science, 2021. [All Versions]. The ability for viruses to mutate and evade the human immune system and cause infection, called viral escape, remains an obstacle to antiviral and vaccine development. Understanding the complex rules that govern escape could inform therapeutic…
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Design of metalloproteins and novel protein folds using variational autoencoders nature.com
Scientific Reports, 2018. [All Versions]. The design of novel proteins has many applications but remains an attritional process with success in isolated cases. Meanwhile, deep learning technologies have exploded in popularity in recent years and are increasingly applicable to…
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Shared computational principles for language processing in humans and deep language models nature.com
Nature Neuroscience, 2022. [All Versions].
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Nature Communications, 2023. [All Versions]. [Project]. Advances in machine learning (ML) and automated experimentation are poised to vastly accelerate research in polymer science. Data representation is a critical aspect for enabling ML integration in research workflows, yet…
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Rational arbitration between statistics and rules in human sequence processing nature.com
Nature Human Behavior, 2022. [All Versions].
AGI & CoCoSci › Papers > Domain Specific Language > Declarative DSL Applications: “Nature, 2023. [All Versions]. Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19, but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the…”